kappa opioid agonistPain Management Peptides
Difelikefalin (Korsuva)
A selective peripherally-restricted kappa opioid receptor agonist. FDA-approved (2021) for pruritus in hemodialysis patients. First-in-class. Does not cross BBB, avoiding central kappa opioid side effects.
anti-pruritickappa-opioid-agonistperipherally-restrictedFDA-approved
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Summary
A selective peripherally-restricted kappa opioid receptor agonist. FDA-approved (2021) for pruritus in hemodialysis patients. First-in-class. Does not cross BBB, avoiding central kappa opioid side eff…