peptide-drug conjugateOncology Peptides
Melflufen (Pepaxti)
A peptide-drug conjugate with a dipeptide linked to alkylating agent melphalan. FDA-approved (2021, later withdrawn) for relapsed multiple myeloma. Uses aminopeptidase overexpression in cancer cells for selective intracellular drug release.
multiple-myelomaalkylating-agentPDCaminopeptidase-targeted
3D Structure
3D Structure
498.4 Da
63 atoms
Lab Tested
No
Harmful Ingredients
0
Contaminants
None
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Mass Spec Profile
ESI-MS (computed)
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Summary
A peptide-drug conjugate with a dipeptide linked to alkylating agent melphalan. FDA-approved (2021, later withdrawn) for relapsed multiple myeloma. Uses aminopeptidase overexpression in cancer cells f…