guanylate cyclase agonistTherapeutic Peptides
Plecanatide (Trulance)
A 16-amino acid peptide analog of uroguanylin. FDA-approved for chronic idiopathic constipation and IBS-C. Activates guanylate cyclase-C to increase intestinal fluid secretion. pH-activated in the small intestine.
constipationIBS-treatmentguanylate-cyclaseFDA-approved
3D Structure
3D Structure
1681.9 Da
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Summary
A 16-amino acid peptide analog of uroguanylin. FDA-approved for chronic idiopathic constipation and IBS-C. Activates guanylate cyclase-C to increase intestinal fluid secretion. pH-activated in the sma…