CRF family peptideNeuropeptides
Urocortin 2
A selective CRF2 receptor agonist. Phase 2 trials for heart failure showed improved cardiac output and reduced systemic vascular resistance. Does not activate the HPA stress axis like CRF1 agonists, avoiding cortisol elevation.
heart-failureCRF2-selectivecardiac-outputhemodynamic
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Summary
A selective CRF2 receptor agonist. Phase 2 trials for heart failure showed improved cardiac output and reduced systemic vascular resistance. Does not activate the HPA stress axis like CRF1 agonists, a…